Therapeutic effect of valsartan and enalapril on QT interval dispersion and premature ventricular contraction in patients with hypertension
- VernacularTitle:缬沙坦与依那普利对高血压患者QT间期离散度与室性早搏的疗效
- Author:
Haixia DU
- Keywords:
Hypertension;
Arrhythmias,cardiac;
Enalapril;
Valsartan
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(3):295-299
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare therapeutic effect of valsartan and enalapril on QT interval dispersion (QTcd) and premature ventricular contraction in patients with hypertension.Methods: A total of 110 patients with essential hypertension were selected from our hospital.According to random number table, they were randomly and equally divided into valsartan group and enalapril group.QTcd and arrhythmia were compared between two groups.Results: Compared with before treatment, there were significant reductions in QT interval, corrected QT interval (QTc) and QTcd in both groups after treatment (P<0.01 all);compared with enalapril group, there were significant reductions in QT interval [(389.45±55.85)ms vs.(339.58±50.58)ms], QTc [(366.58±48.98)ms vs.(319.58±46.58)ms] and QTcd [(34.55±5.08)ms vs.(21.85±3.87)ms] in valsartan group, P<0.01 all.Compared with before treatment, there were significant reductions in SBP, DBP and premature ventricular contraction times (PVCT) in both groups after treatment (P<0.01 all), but there were no significant difference in SBP and DBP(P<0.05 both)between two groups,PVCT of valsartan group was significantly fewer than that of enalapril group [(619.85±202.45) times/d vs.(949.55±198.85) times/d, P=0.001].In valsartan group, there was no significant correlations among SBP, DBP, left ventricular myocardial mass index (LVMI) and premature ventricular contraction (r=0.101, 0.089, 0.104, P>0.05 all);while in enalapril group, occurrence of premature ventricular contraction was significant positively correlated with SBP, DBP and LVMI (r=0.631, 0.599, 0.591, P<0.05 all).No severe adverse reactions occurred in either group.Conclusion: Valsartan can significantly reduce QT interval dispersion, blood pressure and incidence rate of premature ventricular contraction in patients with hypertension.The therapeutic effect is better than that of enalapril, which is worth extending.
