Expression of DAB2IP and β-catenin in bladder urothelial carcinoma and their clinical significance
10.13315/j.cnki.cjcep.2017.04.010
- VernacularTitle:膀胱尿路上皮癌中DAB2IP和β-catenin的表达及临床意义
- Author:
Linfeng ZHENG
;
Xinghao NI
;
Guoping CHENG
;
Shifeng YANG
- Keywords:
bladder neoplasms;
urothelial carcinoma;
DAB2IP;
β-catenin;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(4):398-402
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinical utility of DAB2IP (DOC-2/DAB2 interactive protein)and β-catenin expression in bladder urothelial carcinoma (BUC).Methods The expression of DAB2IP and β-catenin was detected in 104 BUC cases and 40 peritumorial tissues using EnVision two-step immunohistochemical method,and the association with BUC clinicopathological parameters was analyzed.Results The expression of DAB2IP in BUC was significantly less than that of peritumorial normal tissues,and the expression of β-catenin in BUS was significantly higher than that of peritumorial normal tissues (P ＜ 0.05).DAB2IP expression and histologic grading,clinical pathologic staging and 5 years survival rate had statistical significance (P ＜ 0.05).No statistical significance with gender,age,tumor diameter and in patients with incipient/recurrence.β-catenin expression and age,histologic grading,clinical pathologic staging,tumor diameter and 5 years survival rate have statistical significance (P ＜ 0.05).No statistical significance correlated with gender and in patients with incipient/ recurrence,DAB2IP and β-catenin expression in BUC are negatively correlated (P ＜ 0.05).Conclusion In bladder urothelial carcinoma,down-regulation of DAB2IP and up-regulation of β-catenin,are in a negative correlation.Abnormal expression of DAB2IP and β-catenin is correlated with histologic grading,clinical pathologic staging and prognosis.
