Diagnostic value of brain natriuretic peptide and urine microalbuminuria for patients with heart failure
- VernacularTitle:脑钠肽、尿微量白蛋白在心力衰竭患者中的临床诊断价值
- Author:
Zhongdan ZHANG
- Keywords:
Heart failure;
Natriuretic peptide,brain;
Albumins
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(3):269-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe plasma level of brain natriuretic peptide (BNP) and urine microalbuminuria (UMA) level and their correlation in patients with different heart failure (HF).Methods: A total of 180 patients hospitalized in our department were selected.According to NYHA heart function classification and left ventricular function, patients were divided into no HF control group (n=32), diastolic HF (DHF) group (n=72) and systolic HF (SHF) group (n=76).Plasma BNP and UMA levels were measured and compared among above three groups and groups with different NYHA classes, and correlation between BNP and UMA was analyzed.Results: Compared with no HF control group, there were significant rise in plasma BNP level [(15.42±8.04) pg/ml vs.(69.48±55.16) pg/ml vs.(456.23±386.19) pg/ml] and UMA level [(27.92±6.51) mg/L vs.(72.19±26.35) mg/L vs.(142.39±35.41) mg/L] in DHF group and SHF group;and those of SHF group were significantly higher than those of DHF group, P<0.01 all.Along with NYHA class increased(Ⅰ,Ⅱ,Ⅲ,Ⅳ), there were significant rise in plasma BNP level [(45.42±8.04) pg/ml vs.(127.23±79.64) pg/ml vs.(418.35±187.36) pg/ml vs.(1257.62±454.26) pg/ml] and UMA level [(47.92±16.51) mg/L vs.(74.68±27.02) mg/L vs.(131.05±33.68) mg/L vs.(263.14±104.69) mg/L], and there existed significant difference between any two groups, P<0.05 or <0.01.Simple linear regression analysis indicated that plasma BNP level was significant positively correlated with UMA level (r=0.544, P=0.001).Conclusion: Plasma brain natriuretic peptide level is significantly positively correlated with urine microalbuminuria concentrations along with heart failure aggravating, and they possess high value for diagnosis, assessment of severity and prognosis etc.
