Therapeutic effect of alprostadil on renal function in patients with acute myocardial infarction complicated diabetic nephropathy undergoing PCI
- VernacularTitle:前列地尔对急性心梗合并糖尿病肾病PCI患者肾功能的疗效
- Author:
Qian ZHAO
;
Yang ZHUO
;
Ling BIAN
;
Li FAN
;
Alian ZHANG
;
Xin CHEN
;
Zuojuan XU
- Keywords:
Myocardial infarction;
Diabetic nephropathies;
Alprostadil;
Angioplasty,balloon,coronary
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(3):281-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore therapeutic effect of in-hospital intravenous alprostadil injection on patients with acute myocardial infarction (AMI) complicated diabetic nephropathy (DN) undergoing percutaneous coronary intervention (PCI), and evaluate their long-term prognosis.Methods: A total of 80 AMI + DN patients undergoing PCI were selected from our hospital.They were randomly divided into alprostadil group (n=40) and routine treatment group (n=40).Renal function after PCI, cardiac function during hospitalization, serum creatinine (Scr) level on 72h after PCI and incidence of major adverse cardiovascular events (MACE) within one-year follow-up were compared between two groups.Results: Compared with routine treatment group on 72h after PCI, there was significant reduction in Scr level [(126.92±35.28) μmol/L vs.(104.32±22.91) μmol/L], and significant rise in estimated glomerular filtration rate [eGFR, (55.23±31.48) ml·min-1·1.73m-2 vs.(62.14±36.23) ml·min-1·1.73m-2] in alprostadil group, P<0.05 both.Postoperative one-year follow-up indicated that there were no significant difference in incidence rate of MACE and percentage of kidney replacement therapy between two groups, P>0.05 all.Conclusion: Intravenous alprostadil injection based on routine treatment possesses significant therapeutic effect on renal function in AMI + DN patients after PCI, and it's safe
