Clinical characteristics and related factors of pulmonary infection in patients with multiple myeloma
10.16718/j.1009-7708.2017.03.005
- VernacularTitle:多发性骨髓瘤患者肺部感染的临床特点及相关因素分析
- Author:
Shuangling WANG
;
Feng LIU
;
Jiangsheng CHEN
;
Peiwen LU
- Keywords:
multiple myeloma;
pulmonary infection;
agranulocytosis
- From:
Chinese Journal of Infection and Chemotherapy
2017;17(3):253-255
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics of pulmonary infection in patients with multiple myeloma for improving early prevention,diagnosis and treatment.Methods A retrospective analysis was conducted for 70 patients with multiple myeloma admitted to our hospital from January 2012 to April 2015.The clinical data of pulmonary infection were reviewed and analyzed in terms of radiological findings,pathogen distribution,and related risk factors.Results The peripheral white blood cell count and neutrophil percentage could be normal in pulmonary infection of patients with multiple myeloma.However,erythrocyte sedimentation rate increased significantly.Radiological study revealed that infection of bilateral lungs was common.The most frequently identified pathogens were gram negative bacteria,especially Pseudomonas aeruginosa.The main predisposing factors of pulmonary infection were agranulocytosis,stage Ⅲ multiple myeloma,and complications.Conclusions The clinical symptoms of pulmonary infection are diverse in patients with multiple myeloma.Poor immunity is the primary predisposing factor.The common pathogens are gram-negative bacteria.Beta-lactam/beta-lactamase inhibitor combinations or fluoroquinolones are effective empiric treatment for controlling the progression of pulmonary infection.
