Antibiotic resistance and molecular epidemiology of carbapenem-resistant Pseudomonas aeruginosa
10.16718/j.1009-7708.2017.03.012
- VernacularTitle:耐碳青霉烯类铜绿假单胞菌的耐药性及分子流行病学研究
- Author:
Lili YUAN
;
Baixing DING
;
Zhen SHEN
;
Shi WU
;
Xiaogang XU
;
Guanghui LI
- Keywords:
Pseudomonas aeruginosa;
carbapenem-resistant;
antimicrobial resistance;
homology analysis
- From:
Chinese Journal of Infection and Chemotherapy
2017;17(3):289-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antibiotic resistance pattern and molecular epidemiology of carbapenem-resistant Pseudomonas aeruginosa.Methods The antimicrobial susceptibility was measured by agar dilution method for the 104 strains of carbapenem-resistant P.aeruginosa (CRPA) collected from Huashan Hospital.The homology between these strains was evaluated by pulsed field gel electrophoresis (PFGE).Results Of thel04 CRPA strains,85.6％ were resistant to meropenem and 98.1％ to imipenem.These strains also showed various percentages of resistance to amikacin (18.3％),gentamicin (40.4％),ceftazidime (26.9％),cefepime (21.2％),ciprofloxacin (44.2％),levofloxacin (50.0％),piperacillin-tazobactam (19.2％),cefoperazone-sulbactam (26.9％),ticarcillin-clavulanic acid (52.9％),aztreonam (26.9％),and colistin (5.8％).PFGE analysis showed that these strains were divided into 48 types,belonging to 9 clones.Only 3 strains were non-typeable.Clone A was the primary epidemic strain (41.6％,42/101),which was mainly isolated from Neurosurgery,Geriatrics and General Ward.Clone B accounted for 5.9％ (6/101) of the strains.Conclusions Multiple clones of carbapenem resistant Pseudomonas aeruginosa were prevalent in Huashan hospital.Effective infection control approaches should be adopted to prevent the development and the further spreading of antimicrobial resistance.
