Study on the Stability of Baicalin Magnesium Salt
10.6039/j.issn.1001-0408.2017.22.14
- VernacularTitle:黄芩苷镁盐的稳定性研究
- Author:
Haijian XU
;
Yixin LIU
;
Zhixuan WANG
;
Hongru SONG
;
Cuizhe LIU
- Keywords:
Baicalin magnesium salt;
High temperature;
High humidity;
Strong illumination;
Temperature;
pH;
Stability;
HPLC
- From:
China Pharmacy
2017;28(22):3076-3079
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the stability of baicalin magnesium salt. METHODS:The stability of baicalin magnesium salt at high temperature(60 ℃),high humidity(90%),strong illumination(4000 lx),different temperatures(20,37,50,60 ℃) and pHs(6.80,5.70,4.60,4.30,3.90,3.60,3.20) was investigated,and HPLC was used to detect the drug contents. RESULTS:High humidity test indicated that the quality of baicalin magnesium salt was increased by (6.17 ± 0.12)% in the 5th day and in-creased by(6.92±0.05)% in the 10th day. Drug contents in the 10th day were respectively(94.78±0.12)%,(94.79±0.20)%, (94.66±0.15)% in the high temperature,high humidity,strong illumination tests(n=3). In phosphate buffer solution(pH 6.80), baicalin magnesium salt was stable only when the temperature was below 20 ℃;and it was yet stable in pure water(pH 6.76)at 37 ℃. pH stability test showed that the most stable pH was 4.30. CONCLUSIONS:Baicalin magnesium salt has hygroscopicity to some extent. Strong illumination affects the stability more seriously than high temperature and high humidity. The stability of ba-icalin magnesium salt in pure water is superior to in phosphate buffer solution,and the salt is stable in weak acid solution.
