Preparation of Compound Anisodamine and Neostigmine Sustained-release Tablet and Study on the in vitro Drug Release Behavior
10.6039/j.issn.1001-0408.2017.22.28
- VernacularTitle:复方山莨菪碱新斯的明缓释片的制备及体外释药行为研究
- Author:
Yufei LI
;
Xiaoli ZHOU
;
Tuo JIN
- Keywords:
Anisodamine;
Neostigmine;
Compound sustained-release tablet;
in vitro drug-release
- From:
China Pharmacy
2017;28(22):3129-3132
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare the Compound anisodamine and neostigmine sustained-release tablet and study the in vitro drug release behavior. METHODS:Using raceanisodamine and neostigmine methyl sulfate as main medicines,hydroxypropyl meth-yl cellulose as sustained release skeleton material,magnesium stearate as the lubricant,polyvinyl pyrrolidone as the adhesive,pre-gelatinized starch as the thinner,microcrystalline cellulose as the disintegrant and filler,Compound anisodamine and neostigmine sustained-release tablet was prepared by wet granulation method and direct compression method. The in vitro cumulative release rate within 12 h of the 2 main medicines was detected by HPLC method. RESULTS:Compound anisodamine and neostigmine sus-tained-release tablet was successfully prepared,and the in vitro release was basically completed within 12 h,with accumulative re-lease rate of 91.3% for anisodamine and 96.5% for neostigmine. CONCLUSIONS:Compound anisodamine and neostigmine sus-tained-release tablet that can cumulatively release for 12 h is successfully prepared.
