Neutrophil extracellular traps and coagulation dysfunction in sepsis

VernacularTitle:中性粒细胞胞外诱捕网与脓毒症凝血功能障碍的研究进展
Author: Fangxiao ZHANG ; Zhidan ZHANG ; Xiaochun MA
Keywords: Neutrophil extracellular traps; Sepsis; Coagulation dysfunction; Platelet; Endothelial cell
From: Chinese Critical Care Medicine 2017;29(8):752-755
CountryChina
Language:Chinese
Abstract: Neutrophil extracellular traps (NETs) are net-like structure composed of DNA and nuclear proteins, which are produced by activated neutrophils under the circumstances of a variety of pathogens or drugs. As part of defensive mechanism, NETs have been proved to restrict the spread of pathogens and release of antimicrobial molecules. NETs can not only strengthen the adhesion between neutrophils and platelets, promote platelet mediated procoagulant reaction, but also lead to endothelial cell damage and coagulopathy in sepsis. In addition, NETs also plays an important role in pathophysiological processes of venous thrombosis. Therefore, NETs may become the biomarkers of evaluating coagulation dysfunction and potential therapy target in sepsis.