Severe disease of immune imbalance in ICU: persistent inflammation immunosuppression catabolism syndrome

VernacularTitle:ICU严重免疫失衡疾病——持续炎症-免疫抑制-分解代谢综合征
Author: Heyi SU ; Zexun MO ; Zhen CHEN ; Zhenhui GUO
Keywords: Persistent inflammation; Immunosuppression; Catabolism; Immune imbalance
From:Chinese Critical Care Medicine 2017;29(8):760-764
CountryChina
Language:Chinese
Abstract: Terminology of persistent inflammation immunosuppression and catabolism syndrome (PICS) is developed based on the concept of multiple organ failure (MOF), which reflect that the preponderance is gradually reversed from pro-inflammation to anti-inflammation, and eventually the state of simultaneously persistent inflammation and severe immunosuppression appeared. Although the improvement of rescue technology and management increase the early survival rates of patient with critical illnesses, the long-term outcomes of most patients are not optimistic. The patients with PICS are difficult to treat or prevent, and are likely to indolent death and have a rising incidence, which is an important challenge to the intensive care unit (ICU). The paper review the understanding of PICS, summarize the specific changes of immune system in PICS, and explore the immunological markers for early recognition of PICS and judgment of immune state in order to provide new thinking for prevention and control of PICS.