The relationship between coagulation function and birth weight and gestational age in newborn
10.3760/cma.j.issn.1673-4904.2017.08.004
- VernacularTitle:出生胎龄及体质量与新生儿凝血功能的关系
- Author:
Juan ZHAO
;
Binghong ZHANG
- Keywords:
Birth weight;
Gestational age;
Coagulation fuction;
Newborn
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(8):686-689
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the relationship between coagulation function and birth weight and gestational age in newborn. Methods Five hundred premature infants in NICU from June 2015 to June 2016 were enrolled. Perinatal high-risk factors(gestational hypertension, gestational diabetes, placenta previa, spontaneous premature delivery) and general status (gestational age, sex, delivery mode, birth weight)were documented. Blood coagulation function (PT, APTT, FDP, DD, FIB, AT-Ⅲ) was detected within 6 h after birth. The premature infants were divided into three groups according to gestational age, early preterm neonate group (28-30+6 weeks, 48 cases), moderate preterm neonate group (31-33+6 weeks, 125 cases), and late preterm neonate group (34-36+6 weeks, 216 cases). And there were 111 term infants (37- 42 weeks, 111 cases). In addition , the relation between birth weight and coagulation function was analyzed. Sixty-six twins were collected and divided into tow groups according to their weight, the-lighter group and the-heavier group. The coagulation function was analyzed and compared among different gestational age groups. Results There were no differences in perinatal risk factors (P > 0.05). There were significant differences in various coagulation parameters among three groups [APTT: (93.25 ± 21.34), (82.80 ± 21.37), (78.29 ± 17.77), (62.03 ± 13.7) s;FIB: (1.95 ± 0.96), (1.67 ± 0.60), (1.51 ± 2.44), (1.40 ± 0.85) g/L; DD: (2.11 ± 0.64), (1.02 ± 0.33), (0.66 ± 0.31), (0.51 ± 0.25) mg/L;AT-Ⅲ:(25.89 ± 11.80)%, (33.86 ± 11.40)%, (36.65 ± 13.60)%, (45.18 ± 14.82)%] (P<0.05). The levels of APTT, FDP, DD tended to decrease with the increasing of gestational age. The level of FIB and AT-Ⅲtended to increase with the increasing of gestational age. Correlation analysis showed that the levels of APTT, FDP, and DD were negatively correlated with gestational age (P<0.05) and the levels of FIB and AT-Ⅲwere positively correlated with gestational age (P<0.05). In the twins group, no significant difference was showed in different weight (P > 0.05). Conclusions The coagulation function in early life in premature infants is associated with gestational age, and has no relationship with birth weight. The coagulation function of premature infants is in a changing and gradually mature process, which should be monitored dynamically.
