The relationship between the expression of AGGF1 in esophageal squamous cell carcinoma and the clinical features and prognosis
10.3760/cma.j.issn.1673-4904.2017.08.008
- VernacularTitle:AGGF1在食管鳞癌组织的表达与临床特征及预后的关系
- Author:
Yanrong LU
;
Hare AYIGULI
;
Min WU
;
Zengyan LI
;
Zhabihula BAERXIAGULI
- Keywords:
Esophageal neoplasms;
Neoplasms,squamous cell;
Disease attributes;
Prognosis;
AGGF1
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(8):703-706
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of AGGF1 in esophageal squamous cell carcinoma (ESCC) and their relationships with clinical features and prognosis of ESCC. Methods The expressions of AGGF1 in 70 cases of ESCC and 30 cases of normal esophageal tissue were examined using SP immunohistochemical staining and were analyzed according to the clinical features and follow-up data. Results The expressions of AGGF1 in 70 cases of ESCC was significantly higher than those in 30 cases of normal esophageal tissue [54.29%(38/70) vs. 23.33%(7/30)](P=0.004). The expressions of AGGF1 in ESCC were significantly related to the TNM stage, clinical stage and prognosis (P all<0.05). The OS was shorter in the positive teams of AGGF1 than that in the negative teams [(19.7 ± 3.5) months vs. (33.2 ± 4.0) months] (P=0.015). Cox- proportional multivariate analysis showed that positive expressions of AGGF1 and VEGF (P=0.043, 0.024) and clinical stage (P=0.035) were significant prognostic factors in overall survival. Conclusions AGGF1 has high expressions in ESCC, and it is closely related to the clinical features and prognosis of ESCC.
