The research development of high mobility group protein B1 and Toll-like receptor 4 in neuropathic pain
10.3760/cma.j.issn.1673-4904.2017.07.025
- VernacularTitle:高迁移率族蛋白B1和Toll样受体4在神经病理性疼痛中的研究进展
- Author:
Yue MA
;
Yitong LI
;
Yuqing MA
- Keywords:
Neuralgia;
Toll-like receptor 4;
High mobility group proteins;
Review
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(7):665-667
- CountryChina
- Language:Chinese
-
Abstract:
Nerve injury as a kind of tissue damage, inevitably stimulates nerve tissue inflammatory reaction, mediates neural tissue repair and regeneration, and participates in the occurrence of chronic pain. The high mobility group protein B1 (HMGB1) and Toll-like receptor 4 (TLR4) in neurological pain plays an important role, HMGB1-TLR4 pathway is involved in the initiation and progression of neuropathy pain. If the mechanism of HMGB1-TLR4 pathway in the neurological pain is identified, it can provide an effective pain-relieving methods and new target for drugs.
