Focus on the establishment of disease model of Kashin-Beck disease and its application
10.3760/cma.j.issn.2095-4255.2017.07.001
- VernacularTitle:关注大骨节病疾病模型的建立及其应用研究
- Author:
Xiong GUO
- Keywords:
Kashin-Beck disease;
Disease models;
Induced pluripotent stem cells;
Targeted therapy drugs
- From:
Chinese Journal of Endemiology
2017;36(7):469-471
- CountryChina
- Language:Chinese
-
Abstract:
Although the prevalence of Kashin-Beck disease (KBD) has decreased greatly since its discovery,the etiology and pathogenesis of the disease have always been one of the mysteries of the medical world.Facing the difficult situation in obtaining human samples of cartilage tissues and chondrocytes from such as KBD children,we should pay great attention to the spontaneous and induced animal models,and establish the disease model for KBD research using modern molecular biology techniques such as induced pluripotent stem cells,to reproduce the developing process of epiphyseal cartilage,growth plate cartilage and articular cartilage in KBD children,and to verify the high-risk environmental causing factors and specific biological mechanism of the cartilage necrosis and to develop targeted therapeutic drugs for KBD and to enhance the prevention and control levels of the disease.
