Quantitative evaluation of Ki-67 labeling index in glioma with transfer constant derived from dynamic contrast-enhanced MRI
10.3760/cma.j.issn.1005-1201.2017.08.002
- VernacularTitle:动态对比增强MRI容积转移常数定量评估胶质瘤Ki-67标记指数的价值
- Author:
Fei DONG
;
Peipei ZHANG
;
Biao JIANG
;
Qian LI
;
Qiang ZENG
;
Weiwei WANG
;
Peipei PANG
;
Minming ZHANG
- Keywords:
Glioma;
Magnetic resonance imaging;
Ki-67 antigen
- From:
Chinese Journal of Radiology
2017;51(8):568-571
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the value of transfer constant(Ktrans)derived from dynamic contrast-enhanced MRI (DCE-MRI) for quantitative evaluation of Ki-67 labeling index (Ki-67 LI) in glioma. Methods Twenty patients with glioma who underwent DCE-MRI and operation were retrospectively reviewed. The Ktrans value and Ki-67 LI were acquired and correlated using the Spearman correlation test. Also, the Ktrans values were compared between high(larger than 10%)and low(no more than 10%)Ki-67 LI group with Mann-Whitney U test, receiver operating characteristic curves was performed to evaluate the diagnostic value. Results The Ktrans value(0.0165 to 0.8048, median 0.1252)was significantly associated with Ki-67 LI(5%to 50%, median 20%) (r=0.721,P<0.001), and the Ktrans value was significantly higher in high Ki-67 group(0.0810 to 0.8048, median 0.1810)than that in low Ki-67 LI group(0.0165 to 0.1456, median 0.0697)(Z=-3.209, P=0.001). The most predictive Ktrans value differentiated high Ki-67 LI and low Ki-67 LI with an area under the curve(AUC) of 0.945 at a sensitivity of 92.3% and specificity of 85.7%. Conclusion Ktrans value could be used for quantitative evaluation of Ki-67 LI in glioma.
