Preliminary experience of 125I seed strands cavity brachytherapy for ureteral carcinoma
10.3760/cma.j.issn.0254-5098.2017.07.007
- VernacularTitle:125I放射性粒子链腔内近距离放疗输尿管癌的初步经验
- Author:
Dechao JIAO
;
Xinwei HAN
;
Junjie WANG
;
Jianhao ZHANG
;
Yanli WANG
;
Shaofeng SHUI
;
Jianzhuang REN
;
Zongming LI
;
Quanhui ZHANG
;
Rongfang NIU
- Keywords:
125I seed strands;
Brachytherapy;
Ureteral carcinoma
- From:
Chinese Journal of Radiological Medicine and Protection
2017;37(7):508-513
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of 125I seed strands cavity brachytherapy for ureteral carcinoma.Methods To tally 10 patients with ureteral carcinoma underwent Carm CT and DSA guided percutaneous nephrostomy with 125I seed strands cavity brachytherapy.The technical success rate,complications,tumor local control rate,ureteral patency andsurvival time,and compared the Karnofsky scores,Girignon grade,pain score before and after treatment were evaluated.The dose related parameters were compared between pre-and post-treatment.Results 125I seed strands implantation was successfully completed in all patients with technical success rate of 100％.The mean procedure time was (12.3 ±3.8) min.No severe complications such as ureteral perforation,infection,severe bleeding occurred.Local tumor response was CR in 4 cases and PR in 6 cases,showing local control efficiency (CR + PR) 100％ after 2-3 months.Ureteral patency rate was 50％ (5/10).Postprocedure Karnofsky scores,Girignon grades,and pain scores were significantly improved (Z =-2.72,-2.88,-2.83,P＜0.01).The average follow-up time was (14.6 ±6.5) months (5-25 months),tumor progression was observed in 3 cases,stable disease in 7 cases.Nine cases were alive and one died due to multiple organ failure.The differences of D90％,mPD,V100％,V150％,V200％,CI,EI,HI between the preand post-treatment were not statistically significant (P ＞ 0.05).Conclusions 125I seed strands cavity brachytherapy for ureteral carcinoma is an effective and safe procedure without serious complications,and an effective alternative treatment for patients who are unable to undergoor refuse surgery.
