The expression and value of Ax l receptor tyrosine kinase receptor tyrosine kinase in the kidney of patients with lupus nephritis
10.3760/cma.j.issn.1007-7480.2017.07.004
- VernacularTitle:Axl受体酪氨酸激酶在狼疮肾炎组织病理中的表达及其临床意义
- Author:
Qianyu GUO
;
Shanshan LI
;
Huaqun ZHU
;
Bao DONG
;
Yin SU
- Keywords:
Lupus nephritis;
Receptor Pprotein-tyrosine kinases;
Kidney;
glomerulus
- From:
Chinese Journal of Rheumatology
2017;21(7):444-449,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value and the expression of Axl receptor tyrosine kinase (AxlTK) in renal pathology of lupus nephritis (LN) patients. Methods The expression of AxlTK were detected in 29 LN and 10 primary nephritic syndrome (NS) patients using immunohistochemistry in renal tissue. The correlations between the levels of AxlTK on glomeruli and clinical manifestations, laboratory parameters, disease activity, and renal pathology in LN patients were investigated. T test and single factor analysis of variance were used tp compare between groups, and Pearson or Spearman test was used for correlation analysis. Results AxlTK was extensively expressed on surface of mesangial cells, endothelial cells in glomeruli. There was more expression of AxlTK on mesangial cells in LN patients [(7.0 ±2.2)×10-2] than that in primary NS patients [(3.1 ±1.2) ×10-2] (t=5.382, P<0.01). The expression of AxlTK in the glomeruli of LN patients with oral ulcers is higher than that in patients without of ulcers (t=2.259, P=0.032), and it was positively correlated with the anti-nucleosome antibody (AnuA) level in patients (r=0.488, P=0.017). The expression of AxlTK on glomeruli were higher in class Ⅳ and classⅢ of LN patients than that of class Ⅴ, but there was no statistically significant difference between them (P>0.05). Conclusion The expression of Axl TK in glomerular is significantly increased in glomeruli in LN patients. The expression level of AxlTK on glomeruli is correlated with the occurrence of oral ulcers and AnuA. The level of AxlTK expression is related to pathological categories of kidney in LN patients. The results of this study suggest that AxlTK might participate in the pathogenesis of LN.
