Clinical characteristics of adult-onset foveomacular vitelliform dystrophy

VernacularTitle:成人型卵黄样黄斑营养不良的临床特征及研究进展
Author: Jingli GUO ; Yongjin ZHANG
Keywords: Vitelliform macular dystrophy/diagnosis; Disease attributes; Review
From: Chinese Journal of Ocular Fundus Diseases 2017;33(4):431-434
CountryChina
Language:Chinese
Abstract: Adult-onset foveomacular vitelliform dystrophy (AFVD) is characterized by gradually loss of vision,subretinal vitelliform macular lesions and retinal pigment epithelium (RPE) atrophy.The electrooculogram (EOG) is usually normal or reduce slightly.On optical coherence tomography (OCT),there are vitelliform substance which deposited between the photoreceptor layer and the RPE layer,and thinner outer nuclear layer above these deposits.OCT angiography can show the superficial and deep retinal capillaries plexus (DCP) above the yolk-like deposits,the choroidal capillary blood flow is reduced and the DCP blood flow is increased near macular.On indocyanine green angiography (ICG),there is choroidal neovascularization under vitelliform substance at early stage and fluorescence leakage in the corresponding retinal region at late stage.There is no effective treatment for AFVD at present,monogenic gene therapy is the most worth looking forward to.Understanding AFVD clinical manifestations,multi-mode imaging features and new advances in treatment can provide a reference for diagnosis and treatment options