Efficacy and safety of CT-guided 125I seed implantation for treatment of advanced pancreatic cancer: a Meta-analysis
10.3760/cma.j.issn.0254-5098.2017.07.014
- VernacularTitle:CT引导下放射性125I粒子植入治疗中晚期胰腺癌的有效性和安全性的Meta分析
- Author:
Hao WANG
;
Bin HUO
;
Xiaodong HUO
;
Lili WANG
;
Dingkun HOU
;
Li ZANG
;
Jinhuan WANG
;
Shude CHAI
;
Junjie WANG
;
Haitao WANG
- Keywords:
125I seed;
Brachytherapy;
Pancreatic cancer;
Systematic review;
Meta analysis
- From:
Chinese Journal of Radiological Medicine and Protection
2017;37(7):543-549
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the efficacy and safety of 125I seed implantation for treatment of advanced pancreatic cancer.Methods An electronic literatuire search was performed about randomized controlled trials(RCTs) of 125I implantation for treamtent of advanced pancreatic cancer in CNKI,Wanfang Data,CBM,Cochrane Library,PubMed and Embase (from the date of building the database to November 2016).Two investigators independently screened literature,extracted data and assessed the risk bias of included studies,and the Meta-analysis was performed by using Revman 5.3software.Results There were 12 RCTs (n =689) included.Meta-analysis showed that the objective respond rate(ORR) (OR =3.24,95％CI2.33-4.52,P＜0.001),the 6-month survival rate(OR =3.61,95％ CI 1.53-8.52,P =0.003),the 12-month survival rate(OR =4.80,95％ CI 2.40-9.57,P ＜ 0.001) and the relief rate of pain were higher than those in the control group.However,there were no significant differences between both groups in the 2-year survival rate and the adverse reaction rate,which were (OR=2.36,95％ CI 0.47-11.74,P =0.29) and (OR =4.94,95％ CI 1.05-23.23,P =0.04),respectively.Conclusions The limited current evidence showed that 125I implantation for treatment of advanced pancreatic cancer is effective and safety.125I implantation can improve the ORR,short-time survival rate and pain relief rate.In addition,there was no significant increase in the incidence of related adverse events except for seed malposition.Although the quality and quantity of evidences is limited,it merits further study to provide high quality evidences.
