Comparison of clinical efficacy of two noninvasive respiratory support therapy for respiratory distress syndrome in preterm infants
10.3760/cma.j.issn.2096-2932.2017.04.007
- VernacularTitle:两种无创呼吸支持法治疗早产儿呼吸窘迫综合征疗效分析
- Author:
Zhu WANG
;
Weiwei GAO
;
Jia CHEN
;
Yongzhen SHEN
;
Zhongwei YAO
;
Runqiang LIANG
;
Fang XU
;
Tao ZHANG
;
Guoliang XIAO
;
Jie YANG
- Keywords:
Intermittent positive-pressure ventilation;
Infant,low birth weight;
Respiratory distress syndrome,newborn;
High flow nasal cannula;
Infant,premature
- From:Chinese Journal of Neonatology
2017;32(4):269-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy of nasal intermittent positive pressure ventilation (NIPPV) and heated humidified high flow nasal cannula (HHHFNC) in the treatment of respiratory distress syndrome (RDS) among low-birth-weight premature infants.Method From May to December 2015,low-birth-weight premature infants with RDS who were born and treated in our hospital were randomly assigned into NIPPV group and HHHFNC group according to their initial ventilation mode.The incidence of initial treatment failure,the usage of pulmonary surfactant (PS),the parameters of respiratory support treatment and the incidence of complications were analyzed.Result A total of 70 cases with grade Ⅰ ～ llⅢ of RDS were included,including 33 males and 37 females.The birth weight ranged from 1 020 to 2 450 g,with a average of (1 845 ± 475) g.NIPPV and HHHFNC group each had 35 cases.No significant differences existed between the two group in the following items:the rate of mechanical intubation within 72 h (5.7％ vs.11.4％),use of PS (0％ vs.8.6％),incidence of severe apnea (11.4％ vs.14.3％),pneumonia (11.4％ vs.14.3％),the duration of invasive mechanical ventilation [76.3 (30.8,150.4) h vs.97.6 (56.2,142.6) h],non-invasive ventilation [65.0 (43.0,119.0) h vs.96.0 (65.0,134.0) h] and the duration of oxygen therapy [154.0 (47.0,340.0) h vs.148.0 (72.0,327.0) h,it was no (P ＞ 0.05).Also,no significant differences in the incidence of bronchopulmonary dysplasia,necrotizing enterocolitis,retinopathy of prematurity,patent ductus arteriosus,intra-ventricular hemorrhage,nose injury,pneumothorax between the two groups.Conclusion As an initial respiratory support for the treatment of low-birth-weight RDS preterm infants,HHHFNC has similar efficacy and safety with NIPPV,and further clinical research is needed.
