Human umbilical cord mesenchymal stem cell′s transplantation for the treatment of neonatal hypoxic-ischemic encephalopathy
10.3760/cma.j.issn.1673-4408.2017.07.005
- VernacularTitle:人脐带间充质干细胞在HIE治疗中的应用
- Author:
Tingting ZHANG
- Keywords:
Human umbilical cord mesenchymal stem cell;
Newborn;
Hypoxic-ischemic encephalopathy;
Transplantation
- From:
International Journal of Pediatrics
2017;44(7):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal hypoxic-ischemic encephalopathy(HIE)is a common disease in neonatal nervous system injury,which often treated by the traditional measures such as three support′s and three symptomatic treatments.Moreover,there is no specific treatment nowadays.The human umbilical cord mesenchymal stem cells(HUC-MSC)are mixture of multifunctional stem cells from neonatal umbilical cord tissues,which has strong abilities of self-renewal and multilineage differentiation potential.HUC-MSC are easy to harvest and have more sources,low immunogenicity and without ethical problems.It can differentiate into neural cells under certain conditions,secrete neurotrophic factors,repair the damaged brain and promote the recovery of cerebral function.Transplantation of HUC-MSC provides a new way for the treatment of HIE.
