pp65 antigen and human cytomegalovirus infection
10.3760/cma.j.issn.1673-4408.2017.07.010
- VernacularTitle:pp65抗原与人巨细胞病毒感染
- Author:
Pingping YANG
- Keywords:
Human cytomegalovirus;
Phosphoprotein 65;
Antigenemia
- From:
International Journal of Pediatrics
2017;44(7):478-482
- CountryChina
- Language:Chinese
-
Abstract:
HCMV infection can cause hepatopathy,pneumonia,diarrhea,thrombocytopenic purpura,and sensorineural hearing loss(SNHL),with high morbility and mortality.pp65(phosphoprotein 65),a major constitutive protein of virion,is closely associated with viral gene expression,immune evasion and cell metabolism.pp65 antigenemia level has positive correlation with clinical symptom,which can guide the preemptive therapyand improve prognosis,is considered as one of the golden standard methods of active cytomegalovirus infection.In this paper,the pp65 protein properties,pathogenesis,application in diagnosis and prevention are reviewed.
