A new target for gene therapy-splicing factor PUF60
10.3760/cma.j.issn.1673-422X.2017.07.013
- VernacularTitle:剪接因子PUF60——基因治疗的新靶点
- Author:
Cancan ZHANG
;
Rong ZHANG
- Keywords:
Neoplasms;
Genes,myc;
DNA,recombinant
- From:
Journal of International Oncology
2017;44(7):531-533
- CountryChina
- Language:Chinese
-
Abstract:
Poly(U)-binding-splicing factor 60 KDa (PUF60), a U2-related splicing factor that facilitates 3′splice-site recognition at the early stage of spliceosome assembly.High expression of PUF60 is related to the occurrence of multiple tumors, such as colorectal cancer, ovarian cancer, gastric cancer, liver cancer, et al.PUF60 can regulate the expression of c-myc through the core-human transcription factor Ⅱ basal transcription factor.Anti-PUF60 antibodies are detected in the sera of patients with early-stage and recurrent tumor, and the levels are significantly decreased after the operation.PUF60 can be used as a combined or independent test index for the diagnosis of cancer, which can be a potential new target for gene therapy.
