Therapeutic resistance of breast cancer stem cells and its related signaling pathway
10.3760/cma.j.issn.1673-422X.2017.07.017
- VernacularTitle:乳腺癌干细胞的治疗抵抗及其信号通路
- Author:
Yalan TONG
;
Tao HAN
;
Zhongzheng LIU
;
Gang YUAN
;
Yan LIANG
;
Zhaozhe LIU
;
Xiaodong XIE
;
Chengshan YUE
- Keywords:
Breast neoplasms;
Neoplastic stem cells;
Targeted therapy
- From:
Journal of International Oncology
2017;44(7):544-546
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer stem cells (CSCs) are the main causes leading to the failure of treatment of breast cancer and play important roles in the progression of breast cancer and drug resistance, which are closely related to the therapeutic resistance of radiotherapy and chemotherapy, and endocrine therapy.The metastatic potential and therapeutic resistance of CSCs are associated with epithelial mesenchymal transition and Hedgehog, Wnt, interleukin-6/signal transduction and tanscriptional activation factor 3, transforming growth factor-β and other signaling pathways.While some of the targeted drugs targeting these signaling pathways are undergoing clinical transformation, which is expected to provide new approach for the clinical treatment of breast cancer.
