Role of autophagy in acute kidney injury
10.3760/cma.j.issn.1673-4408.2017.07.003
- VernacularTitle:细胞自噬在急性肾损伤中的作用
- Author:
Manman CHU
- Keywords:
Acute kidney injury;
Autophagy
- From:
International Journal of Pediatrics
2017;44(7):451-455
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury(AKI)is a major kidney disease associated with poor clinical outcomes.The pathogenesis is characterized by tubular cell injury and death.Recent studies have demonstrated autophagy induction in proximal tubular cells during acute kidney injury.In the pharmacological or autophagy-related gene knockout AKI models,autophagy has been demonstrated to reduce the cell death and protect kidney through inhibiting the inflammatory response and removing the injury organelles.However,some studies suggest that autophagy has damage effects on the AKI.In conclusion,illuminating the roles and regulatory mechanism of autophagy in the AKI may provide the important theoretical clue for the therapy and prognosis of AKI.
