17q21 loci gene and childhood asthma
10.3760/cma.j.issn.1673-4408.2017.07.008
- VernacularTitle:17q21位点基因在儿童哮喘中的研究进展
- Author:
Qian CAO
;
Lili ZHUANG
- Keywords:
Childhood asthma;
17q21;
Orosomucoid like 3;
Gasdermin B;
Single nucleotide polymorphism
- From:
International Journal of Pediatrics
2017;44(7):471-474
- CountryChina
- Language:Chinese
-
Abstract:
Asthma,a chronic inflammatory airway disease,is influenced by both genetic and environmental factors.It is a complex disease that involves the interplay among multiple physiological processes.Currently,it has been identified that 17q21 loci genes especially orosomucoid like 3 (ORMDL3) and gasdermin B (GSMDB) are strongly linked with the susceptibility and severity of childhood asthma by using of the Genome-Wide Association Study (GWAS).Furthermore,a better understanding of the molecular mechanism contributes to the asthma target therapeutics and precision medicine.This review summarizes the 17q21 loci genes associated with the susceptibility,severity,and race specificities of childhood asthma.
