Pathogenesis of t(8;21) acute myeloid leukemia and the progress of next generation sequencing technique in leukemia

VernacularTitle:t(8;21)白血病的发病机制及二代测序技术在白血病中的应用进展
Author: Sai HUANG ; Cong FENG ; Yan LI ; Honghao GAO ; Guofeng CHEN ; Yonghui LI ; Li YU
Keywords: leukemia; oligonucleotide array sequence analysis
From: Medical Journal of Chinese People's Liberation Army 2017;42(5):472-476
CountryChina
Language:Chinese
Abstract: Acute myeloid leukemia (AML),the most common disease in acute leukemia,is a highly heterogeneous invasive hematological disease.The t(8;21)(q22;q22) translocation is the most common chromosomal translocation in AML,generating AML1-ETO fusion gene and encoding AML1-ETO fusion protein.This article summarizes the two-hit hypothesis in AML occurrence,the pathogenesis of t(8;21)AML,all features involved in t(8;21)AML,and the function of the components in AML1-ETO fusion protein,providing important basic information for the treatment and prognosis of t(8;21)AML.Meanwhile,this article also summarizes the progress of next generation sequencing technique in leukemia,providing a new technique for the accurate therapy of (8;21)AML.