Advances in childhood T-cell acute lymphoblastic leukemia and inhibitors targeting PI3K-Akt-mTOR signaling pathway

VernacularTitle:儿童T系急性淋巴细胞白血病与PI3K-Akt-mTOR信号通路抑制剂的相关研究进展
Author: Danqing LUO
Keywords: Leukemia; T-cell; Child; Antistatic agents; PI3K-AKT-mTOR signaling pathway
From: Journal of Leukemia & Lymphoma 2017;26(6):380-384
CountryChina
Language:Chinese
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is a hematopoietic malignancy derived from T precursor cells. Morbidity of children accounted for 15%of ALL. Studies have found that PI3K-Akt-mTOR signaling pathway is associated with the occurrence of T-ALL, cell proliferation, cell apoptosis and drug resistance. The PI3K-Akt-mTOR signaling pathway inhibitors, which can target to inhibit T-ALL cell proliferation in the treatment of T-ALL children, plays an effective cytotoxic role. By shortening the duration of treatment, it can significantly improve the quality of life of children with T-ALL and reducing disease recurrence. It is a more effective way for traditional chemotherapy resistant T-ALL children patients.