Expression ofβ1 integrin, Rac1, and RhoA in invasive micropapillary breast carcinoma
10.3969/j.issn.1000-8179.2017.14.356
- VernacularTitle:乳腺浸润性微乳头状癌组织β1 integrin及Rac1和RhoA表达的研究
- Author:
Xia ZHENG
;
Bingbing LIU
;
Fanfan MENG
;
Shuai LI
;
Feng GU
;
Li FU
- Keywords:
invasive micropapillary carcinoma;
metastasis;
β1 integrin;
Rac1;
RhoA
- From:
Chinese Journal of Clinical Oncology
2017;44(14):695-700
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and significance ofβ1 integrin, Rac1, and RhoA in invasive micropapillary breast carcinoma (IMPC). Methods:Immunohistochemical staining was performed to detect the expression ofβ1 integrin, Rac1, and RhoA in 89 patients with IMPC and 90 patients with invasive ductal carcinoma-not otherwise specified (IDC-NOS) who were treated between January 2007 and December 2008 in Tianjin Medical University Cancer Institute and Hospital. The relationship among the three proteins and the expression ofβ1 integrin, Rac1, and RhoA with clinicopathological features were determined. Results:β1 integrin (78.7%) and Rac1 (76.4%) were highly expressed in patients with IMPC. This expression was significantly higher than that in patients with IDC-NOS (63.3%and 54.4%). Statistical difference was found between the two groups (P<0.05). Positive rate of RhoA (68.5%) in patients with IMPC was also statistically higher than that in patients with IDC-NOS (44.4%, P=0.001). In patients with IMPC, the expression ofβ1 integrin and Rac1 was positively associated with lymph node metastasis (P<0.05), while the expression ofβ1 integrin was positively correlated with Rac1 expression (P=0.006). Expression of RhoA was positively correlated with lymph node involvement and ER and PR status (P<0.05). However, no correlation was found between RhoA expression and the expression ofβ1 integrin and Rac1 (P>0.05). Conclusion:Thus,β1 integrin, Rac1, and RhoA were overexpressed and might play an important role in the high frequency of metastasis in patients with IMPC. These proteins could be considered as biomarkers for the prognosis and new targets for IMPC therapy.
