Effect of Tianteng Jiangya decoction on blood pressure and vascular endothelial function in essential hypertension
10.3760/cma.j.issn.1008-6706.2017.16.016
- VernacularTitle:天藤降压汤对原发性高血压患者血压及血管内皮功能的干预研究
- Author:
Changqing CAI
;
Xuehua FANG
- Keywords:
Hypertension;
Tianteng jiangya decoction;
Vascular endothelial growth factors
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(16):2460-2464
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Tianteng Jiangya decoction on vascular endothelial function in essential hypertension.Methods 70 patients with essential hypertension were enrolled in this study,they were divided into study group(35 cases)and control group(35 cases)according to the random number table.The control group was treated with levamlodipine for 8 weeks,the study group was treated with Tianteng Jiangya decoction on the basis of the control group for 8 weeks.Then,the DBP and SBP were observed before and after treatment.The ET-1 and nitric oxide(NO)were measured by radioimmunoassay and spectrophotometry.The curative effect and symptom of both two groups were evaluated.Results The levels of DBP and SBP in the study group and the control group were(80±4)mmHg and(88±5)mmHg,(118±13)mmHg and(131±15)mmHg,respectively,which were significantly lower than those before treatment(t=7.263,4.488,9.227,4.422,all P<0.05).The levels of DBP and SBP in the study group were significantly lower than those in the control group(t=4.776,5.527,all P<0.05).The NO level in the study group was(80.37±7.27)μmol/L,,which was significantly lower than that before treatment(t=4.167,P<0.05).The ET-1 level in the study group was(94.26±9.08)ng/L,which was significantly lower than that before treatment(t=3.819,P<0.05).There was no significant change in endothelium function between before and after treatment in the control group(t=1.686 and 1.612,all P>0.05).The total effective rates of dizziness,headache,five upset hot,forgetfulness in the study group and the control group were 89.47% and 64.71%,90.00% and 63.16%,88.89% and 50.00%,82.35% and 47.37%,respectively,the differences were statistically significant(x2=6.422,6.585,6.247,6.456,all P<0.05).The total effective rate of the study group was 94.29%,which was significantly higher than 71.43% of the control group,the difference was statistically significant(x2=9.622,P<0.01).Conclusion Tianteng Jiangya decoction can effectively control the blood pressure of patients with essential hypertension,improve the efficacy of traditional Chinese medicine and vascular endothelial function,has obvious advantages,it is worthy of clinical use.
