Effects of carbon-coated iron nanoparticles carrying cisplatin on the chemotherapy sensitivity of lung cancer cells
10.7652/jdyxb201704010
- VernacularTitle:铁碳纳米粒介导顺铂对肺癌细胞化疗敏感性的影响
- Author:
Xiaomin DANG
;
Zhongmin SUN
;
Lan YANG
;
Dong SHANG
;
Hui ZHONG
;
Hao HU
;
Jianxin GUO
- Keywords:
carbon-coated iron nanoparticle;
cisplatin;
lung cancer;
Caspase 3;
Survivin
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2017;38(4):517-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the inhibitory effect of carbon-coated iron nanoparticles carrying cisplatin on the growth of NCI-H446 lung cancer cells and expressions of Caspase 3 and Survivin mRNA.Methods NCI-H446 lung cancer cells were treated with iron-carbon nanoparticles and/or cisplatin.The cell viability was detected by MTT method,and the mRNA expressions of Caspase 3 and Survivin were measured with RT-PCR.Results Cisplatin could inhibit the growth of NCI-H446 lung cancer cells,and the inhibitory effect was stronger when it was combined with the iron-carbon nanoparticles.The cells had apoptosis.The mRNA expression of Caspase 3 of NCI-H446 lung cancer cells was remarkably enhanced after treatment with iron-carbon nanoparticles combined with cisplatin,while the mRNA expression of Survivin was notably weakened (P＜0.05).Conclusion Carbon-coated iron nanoparticles carrying cisplatin could significantly increase the chemotherapy sensitivity of cisplatin on NCI-H446 lung cancer cells and enhance the therapeutic efficacy of chemotherapy drugs.
