Regional homogeneity on resting state fMRI in patients with uremic restless legs syndrome
10.7652/jdyxb201704025
- VernacularTitle:尿毒症不宁腿患者静息态脑功能磁共振局部一致性研究
- Author:
Jianxin GUO
;
Dun DING
;
Xueying MA
;
Peng LI
;
Ming ZHANG
- Keywords:
fMRI;
restless legs syndrome;
regional homogeneity;
maintenance hemodialysis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2017;38(4):591-595
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study neuromechanism for uremic restless syndrome (URLS),functional MRI (fMRI) analysis and were used to explor main activity.Methods Resting state functional magnetic resonance imaging (MRI) was performed on 29 patients with uremic restless legs syndrome and 25 healthy controls.The values of the regional homogeneity (ReHo) of the two groups were calculated and analyzed statistically.Result As compared with the control group,patients with uremic restless legs syndrome showed emotional and mental abnormality.Increased ReHo values in bilateral supplementary motor area,bilateral thalamus,left insular lobe,left hippocampus (P＜0.05),and decreased ReHo values in anterior cingulate gyrus,bilateral posterior central gyrus,right amygdala were found in patients with uremic restless legs syndrome (P＜0.05).The severity score of RLS was respectively positively correlated with dialysis duration (r =0.57,P =0.002),PTH level (r =0.419,P =0.033)BAI (r =0.528,P=0.006),and BDI (r =0.567,P =0.003).Conclusion Neuronal activity in related brain area in patients with uremic restless legs syndrome were found.This abnormality provides an objective diagnostic basis for the explanation of restless legs syndrome in maintenance hemodialysis patients.
