Effects of Wendan decoction on depression-like behavior and cerebral monoamine neurotransmitters in a rat model of Parkinson's disease
10.7652/jdyxb201704028
- VernacularTitle:温胆汤对帕金森病模型大鼠抑郁样行为及脑内单胺类神经递质的影响
- Author:
Moran WANG
;
Yunong FU
;
Zhiwei CUI
;
Huan JIAN
;
De XIE
;
Jin ZHAO
;
Huisheng WANG
;
Tao WANG
- Keywords:
Parkinson's disease;
Wendan decoction;
depression;
monoamine neurotransmitter;
rat
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2017;38(4):606-610
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Wendan decoction (WD) on depression-like behavior in a rat model of Parkinson's disease (PD) and explore the related mechanism.Methods Rodent model of PD was established by unilaterally lesioning medial forebrain bundle with 6-hydrodopamine.After intragastric administration with WD,the rats's behavior changes were detected by the open field test,sucrose preference test and forced swimming test;the contents of monoamine neurotransmitters in the rat brain were assessed by high-performance liquid chromatography with electrochemical detection.Results Compared with those of sham-operated rats,the horizontal and vertical activities of the PD model rats decreased significantly,and sucrose consumption decreased significantly,but immobility time during forced swimming was significantly prolonged.The contents of dopamine (DA),5-hydroxytryptamine (5-HT) and noradrenaline (NA) in the medial prefrontal cortex (mPFC) and DA in the striatum decreased significantly.After administration of WD for 2 weeks,the immobility time of the PD model rats was significantly decreased,sucrose consumption increased significantly;DA,5-HT and NA levels in the mPFC increased significantly.Conclusion WD improves the depression-like behavior in PD model rats,and the mechanisms may involve the regulation of monoamine neurotransmitters in mPFC.
