Long noncoding RNA EPB41L4A-AS2 associated with the prognosis of tumors
10.11904/j.issn.1002-3070.2017.03.003
- VernacularTitle:长链非编码RNA EPB41L4A-AS2对乳腺癌的预后研究
- Author:
Qianlin CHEN
;
Da PANG
- Keywords:
Long non-coding RNA;
Breast cancer;
EPB41L4A-AS2
- From:
Practical Oncology Journal
2017;31(3):205-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective The relationship between the clinicopathological features and the prognosis of breast cancer patients was evaluated by the expression of EPB41L4A-AS2 in breast cancer tissues.Methods The relationship between the expression of EPB41L4A-AS2 and the clinical features of breast cancer was evaluated by using the genome meta analysis,TCGA and Gene Expression Library(GEO) datasets.The correlation between EPB41L4A-AS2 and apoptotic pathway was verified by Western blotting.Results The results from Meta -analysis,TCGA and GEO datasets showed that EPB41L4A-AS2 was low in breast cancer tissues and was positively correlated with poor clinical and pathological features.EPB41L4A-AS2 was confirmed an association with the classical apoptosis pathway in breast cancer cell lines.In the meta-analysis of GEO,we found the high expression of EPB41L4A-AS2 with good prognosis.Conclusion EPB41L4A-AS2 inhibits tumor formation and has a high value in clinical prognosis of breast cancer.
