Research progress of the relationship between granule head-like 2 gene and tumor in Drosophila melanogaster
10.11904/j.issn.1002-3070.2017.03.013
- VernacularTitle:似果蝇粒状头样2基因与肿瘤关系的研究进展
- Author:
Mingli WEI
;
Jun ZENG
- Keywords:
Grainyhead-like 2;
Neoplasm;
Epithelial-mesenchymal transition
- From:
Practical Oncology Journal
2017;31(3):254-257
- CountryChina
- Language:Chinese
-
Abstract:
Grainhead-like 2 (GRHL2) is one of the homologous genes of Drosophila granule head-like gene in mammals,which is a kind of Drosophila granule head transcription factor.In normal organisms,GRHL2 is involved in the regulation of epithelial cell differentiation and development.In tumors,GRHL2 is complex.GRHL2 not only inhibits tumorigenesis,but it also promotes tumor formation,especially epithelial origin of malignant tumors mostly involving epithelial-mesenchymal transition (EMT) process.Further study of the relationship between GRHL2 and tumor will provide a new idea for the clinical diagnosis and treatment of cancer patients.The relationship between GRHL2 and tumor is reviewed in this paper.
