Self renewal, repair and malignant transformation of intestine epithelial cells
10.11904/j.issn.1002-3070.2017.03.015
- VernacularTitle:肠道上皮细胞再生修复与恶性转化的研究现状
- Author:
Meng JIANG
- Keywords:
Intestine mucosal;
Chronicinflammation;
Malignant transformation
- From:
Practical Oncology Journal
2017;31(3):262-267
- CountryChina
- Language:Chinese
-
Abstract:
Chronic inflammation of intestine mucosal has been considered as a critical component of colorectal cancer development.Recently,the studies based on high throughput sequencing of colorectal cancer patients released a potential molecular subtype of colorectal cancer,characterized by wound healing and innate immune genes.It suggests that a probably mechanism described by a subset of cells that may be dependent on inflammatory cells and cytokines of tumor development,extremely expanding our insight of cell malignant transformation,and highlight the anti-inflammation treatment.This article will review the normal mechanism of intestine mucosal renewal,wound healing and malignant transformation.
