Effects of Danhong Injection Combined with Low Molecular Heparin on Clinical Symptoms,Serum In-flammatory Factors and Lung Function of Elderly Patients with COPD
10.6039/j.issn.1001-0408.2017.21.12
- VernacularTitle:丹红注射液联合低分子肝素对老年COPD患者的临床症状、血清炎症因子及肺功能的影响
- Author:
Yuan HUANG
;
Lu LI
- Keywords:
Elderly;
Chronic obstructive pulmonary disease;
Danhong injection;
Low molecular weight heparin;
Inflammatory factor;
Lung function
- From:
China Pharmacy
2017;28(21):2922-2925
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of Danhong injection combined with low molecular weight heparin (LM-WH) on clinical symptoms,serum inflammatory factors and lung function in elderly patients with chronic obstructive pulmonary disease (COPD). METHODS:A total of 146 elderly patients with COPD were randomly divided into observation group and con-trol group,with 73 cases in each group. Both groups received conventional treatment. On this basis,control group was given Dan-hong injection 30 mL,intravenous drip,once a day. Observation group was additionally given LMWH sodium injection 5000 IU, subcutaneously,twice a day,on the basis of control group. Both groups were treated for 14 d. Clinical efficacies of 2 groups were observed and compared. The clinical symptom score,the levels of IL-6,IL-8,TNF-α,FEV1,FEV1/FVC,pa(O2),pa(CO2) and the occurrence of ADR were compared before and after treatment. RESULTS:After treatment,the total response rate of observa-tion group was significantly higher than that of control group(93.15%vs. 78.08%,P<0.05). Before treatment,there was no statis-tical significance between above indexes (P>0.05). After treatment,individual clinical symptom score,total clinical symptom score,the levels of IL-6,IL-8,TNF-α,pa(CO2)in 2 groups were significantly lower than before;the observation group was signif-icantly lower than the control group;FEV1,FEVl/FVC,pa(O2) were significantly higher than before,and the observation group was significantly higher than the control group,with statistical significance (P<0.05). CONCLUSIONS:Based on conventional treatment,Danhong injection combined with LMWH is effective in the treatment of senile COPD,and can significantly improve the clinical symptoms,serum inflammatory factors levels and pulmonary function with good safety.
