Clinical effect of oral mifepristone combined with intramuscular injection of methotrexate in the treatment of cesarean scar pregnancy
10.3760/cma.j.issn.1008-6706.2017.17.021
- VernacularTitle:米非司酮联合甲氨蝶呤治疗剖宫产术后子宫瘢痕妊娠的临床效果观察
- Author:
Jianhua WANG
;
Weimin WANG
- Keywords:
Mifepristone;
Methotrexate;
Cicatrix;
Pregnancy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(17):2643-2646
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of mifepristone combined with intramuscular injection of methotrexate in the treatment of cesarean scar pregnancy.Methods Fifty-six patients with uterine scar pregnancy after cesarean section were divided into observation group and control group by random number method.The control group was intramuscularly injected methotrexate,the observation group was given methotrexate combined with mifepristone therapy.The therapeutic effect,blood β human chorionic gonadotropin(β-HCG) decreased to normal time,vaginal bleeding time,mass size were observed.Results After treatment,the serum β-HCG decreased to normal time[(15.96±3.71)d] and vaginal bleeding time[(5.12±2.08)d] of the observation group were significantly shorter than those of the control group [(25.42±4.02)d,(7.39±3.37)d],the mass size of the observation group [(1.88±0.15)cm] was also significantly smaller than (2.14±0.33) cm of the control group,and there were significant differences between the two groups(t=4.3142,3.0331,3.7954,all P<0.05).Conclusion Mifepristone combined with intramuscular injection of methotrexate has significant effect on uterine scar pregnancy after cesarean section.