Clostridium difficile Infection: Is Clinical Phenotype Associated with Bacterial Toxin?
10.3969/j.issn.1008-7125.2017.07.001
- VernacularTitle:艰难梭菌感染:临床表型与细菌毒素相关吗?
- Author:
Ye CHEN
;
Qianyun LIN
- Keywords:
Clostridium difficile;
Phenotype;
Bacterial Toxins;
Genes;
Gene Regulatory Networks
- From:
Chinese Journal of Gastroenterology
2017;22(7):385-389
- CountryChina
- Language:Chinese
-
Abstract:
Clostridium difficile (C.difficile) infection is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis.C.difficile-associated disease (CDAD) is mediated mainly by two bacterial toxins, TcdA and TcdB, which cause the diarrhea, as well as colitis and even intestinal necrosis.It has been indicated that level of C.difficile toxin is an important factor influencing the clinical phenotype of CDAD, however, the exact association between toxin and clinical phenotype remains unclear.In this article, we summarized the clinical phenotype of CDAD, the structure, function and regulatory mechanism of C.difficile toxin and discussed the relationship between C.difficile toxin and clinical phenotype, which may help to understand the pathogenic mechanism and provide possible therapeutic target for C.difficile infection.
