Action mechanisms of continuous renal replacement therapy for sepsis

VernacularTitle:连续肾脏替代治疗对脓毒症的作用机制探讨
Author: Zhiyong PENG
Keywords: Continuous renal replacement therapy; Sepsis; Regulation of immunity; Mechanism
From: Journal of Medical Postgraduates 2017;30(7):698-702
CountryChina
Language:Chinese
Abstract: Sepsis is a life-threatening organ dysfunction caused by dysregulated immune response to infection, which has high rates of morbidity and mortality.The imbalance between the response to inflammation and that to anti-inflammation is one of the most important pathophysiological processes in patients with sepsis.Despite the variety of its treatment options, their therapeutic effects remain unsatisfactory.Continuous renal replacement therapy (CRRT) is gaining a wider application in critical care medicine, especially in the treatment of sepsis, which can significantly increase the survival rate of sepsis patients by immunity modulation, organ support, and internal environment stabilization, so as to improve the immune disorder, protect the organ functions, and maintain homeostasis in the body.