Research Progress in the Drugs for Drug-resistant Herpesviruses
- VernacularTitle:抗耐药疱疹病毒药物的研究进展
- Author:
Ling HUANG
;
Yimeng ZHANG
;
Xiaohua ZHANG
;
Jian LI
;
Jinchun SONG
- Keywords:
Herpesviruses;
Drug-resistance;
Polymerase;
New antiviral targets
- From:
China Pharmacist
2017;20(7):1289-1292
- CountryChina
- Language:Chinese
-
Abstract:
Herpesviruses is one of the most common human infectious diseases, which can be divided into different types based on clinical infection degree.Herpes simplex virus usually results in buccal and genital mucocutaneous infections, while cytomegalovirus is the most common opportunistic pathogen associated with significant morbidity and mortality in immunocompromised hosts, especially in transplant and cancer patients.Although nucleoside analogues are effective antiviral drugs, the emergence of drug-resistant viruses has created a barrier for the treatment of herpesviruses infections, especially in immunocompromised patients.Therefore, novel therapeutic agents are needed to avoid the limitations of drug resistance.In this article, research progress in the therapeutic agents for drug-resistant herpesviruses was reviewed from the aspects of non-nucleoside analogues, novel antiviral targets and newly antiviral mechanisms.
