Preparation and characterization of multi-functional targeting nano-carrier based on pH-redox tumor microenvironment
10.11665/j.issn.1000-5048.20170309
- VernacularTitle:基于肿瘤微环境pH-redox智能响应多功能纳米靶向载体的制备及表征
- Author:
Jingfang SUN
;
Chunjing GUO
;
Yunduan ZHANG
;
Xiaoyan SONG
;
Jiantao LYU
;
Jungang YIN
;
Daquan CHEN
- Keywords:
pH-sensitivity;
redox-sensitivity;
targeting carrier;
micelles;
tumor microenviroment;
preparation;
characterization
- From:
Journal of China Pharmaceutical University
2017;48(3):305-310
- CountryChina
- Language:Chinese
-
Abstract:
In order to construct a novel multifunctional targeting nano-carrier based on pH-redox characteristics of tumor microenvironment,ketone bonds and disulfide bonds were bonded to the oligomeric hyaluronic acid (oHA) being sensitive to pH and the reduction environment.The chemical structure of oligomeric hyaluronic acid-8-mercaptomenthone 1,2-glycerolketal (oHMST) was characterized by 1H NMR,IR and ESI-MS.Curcuminloaded micelles were prepared by dialysis.The single factor investigation was carried out on the dosage form.Some properties,including particle size zeta potential,the morphology of micelles,and pH-sensitivity were studied.The materials were synthesized successfully.The micelles were spheric with a diameter of about 100 nm.The Zeta potential of the micelles was-(21.97 ± 1.08) mV.The in vitro test showed that oHMST carriers have good pH-sensitivity and redox-sensitivity.
