Improvement of preparing technique for compound glycyrrhiza oral solution

VernacularTitle:复方甘草口服溶液制备的工艺改进
Author: Haibing LI ; Yanbing XIE ; Hongbing XIAO ; Xiuting YANG
Keywords: compound glycyrrhiza oral solution; morphine; sodium sulfite; stabilizer
From: Journal of International Pharmaceutical Research 2017;44(6):660-662
CountryChina
Language:Chinese
Abstract: Objective To obtain a clear and qualified compound glycyrrhiza oral solution by using NaSO3 and EDTA as stabi-lizers and Tween80 as solubilizer so as to solve the problem of morphine content instability. Methods NaSO34g and EDTA 0.6 g as stabilizers,and Tween803 g as solubilizer were added in the traditional method. The pH of the solution was adjusted to 8.0. Then the solution was obtained and filled in the brown polyester bottle. Results The preparation was clear,qualified and the content of mor-phine was steady. Conclusion The improved method is feasible,simple,stabilized and suitable for manufacturing.