Preparation and property of gelatin hydrogel loaded with AgSD-nanocrystal

Jie Shao; Yulian XU; Liwei Wang; Daihong Guo

Return

Preparation and property of gelatin hydrogel loaded with AgSD-nanocrystal

VernacularTitle:载磺胺嘧啶银纳米晶体明胶凝胶的制备及其性质测定
Author: Jie SHAO ; Yulian XU ; Liwei WANG ; Daihong GUO
Keywords: gelatin; silver sulfadiazine; dressing; nanocrystal
From: Journal of International Pharmaceutical Research 2017;44(6):629-633
CountryChina
Language:Chinese
Abstract: Objective To prepare a silver sulfadiazine(AgSD)-nanocrystal loaded hydrogel with gelatin as the main raw mate-rial,genipin as crosslinker,and test its physicochemical property and drug release characteristics. Methods AgSD-nanocrystal was prepared by ball milling,the particle size and polydispersity index were determined,the solubility was studied by an ultra perfor-mance liquid chromatography(UPLC)method and the microstructure was observed with transmission electron microscope(TEM);drug loaded gelatin hydrogel in different crosslinking degrees were prepared,the dissolution rate was studied in the same way as AgSD-nanocrystal and the possible dissolution mechanism was analyzed by fitting curves;the microstructure was observed by scanning elec-tron microscope(SEM). After 6 weeks,with the same method,all the above mentioned properties of drug loaded hydrogel and AgSD-nanocrystal suspension were determined repeatedly,and at the same time their stability was tested. Results After nanocrystalliza-tion,the polydispersity index of AgSD was 0.211,the mean particle size was about 267.8 nm,the dissolution rate greatly increased within 6 hours compared with that of AgSD bulk powder. There was a negative correlation between dissolution rate and crosslinking de-gree,and the nanoparticle gel's curve was higher than that of the bulk. In terms of stability,AgSD-nanocrystal in hydrogel was almost in the original state in SEM,while those in suspention had an increasing particle size and decreasing dissolution rate. Conclusion The stability and dissolution of the new drug loaded hydrogel are good,and its data can be used as reference for relevant study.