A Ribavirin Potentiometric Sensor Based on MolecularlyImprinted Polymers Doped with Graphene Oxide Film
10.11895/j.issn.0253-3820.170063
- VernacularTitle:基于分子印迹聚合物掺杂氧化石墨烯膜的利巴韦林电位传感器
- Author:
Jianwen LI
;
Shoulian WEI
;
Nana CHEN
- Keywords:
Ribavirin;
Imprinted polymer;
Graphene oxide;
Potentiometric sensor;
Feed
- From:
Chinese Journal of Analytical Chemistry
2017;45(7):1031-1037
- CountryChina
- Language:Chinese
-
Abstract:
Molecularly imprinted polymer (MIP) was synthesized by precipitation polymerization using ribavirin as the template molecule and methacrylic acid as the functional monomer.The sensitive film of ribavirin electrode was constructed by molecularly imprinted polymer doped with graphene oxide as the ionophore, poly(vinylchloride) (PVC) as matrix and dioctyl sebacate for plasticizer.The results showed that the best performance of the electrode was obtained when the sensitive film compositions were 100.8 mg of MIP, 14.7 mg of GO, 450.8 mg of PVC and 901.6 mg of dioctyl sebacate, and the inner filling solution composition was 0.1 mol/L NaCl + 0.05 mol/L NaAc-0.05 mol/L HAc + 1.0×10.-5 mol/L ribavirin solution.The electrode showed a near-Nernstian slope of 45.565 mV/decade for ribavirin over the range of 1.0×10.6-1.0×10.-4 mol/L and a detection limit of 1.0×10.-7 mol/L.The electrode could be used in the pH range of 3 to 5 with response time of less than 3 min.The developed electrode exhibited high selectivity for ribavirin and was successfully applied to the determination of ribavirin in feed and injection with recoveries of 90%-110% and RSD of 3.0%-7.9%.
