Advances of lncRNA in immune cells and autoimmune diseases
10.11665/j.issn.1000-5048.20170319
- VernacularTitle:lncRNA在免疫细胞及自身免疫性疾病中的研究进展
- Author:
Dongmei YU
;
Wei GUO
;
Wen LEI
;
Yaoyao GE
;
Yucong CHEN
;
Xiangdong GAO
;
Wenbing YAO
- Keywords:
lncRNA;
immune cells;
autoimmune diseases;
immune regulation
- From:
Journal of China Pharmaceutical University
2017;48(3):371-376
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNA (lncRNA) is a newly identified non-coding RNA subfamily with various regulatory functions.Recent evidence has shown the fundamental role of long noncoding RNAs in affecting the development of diseases at different levels,from gene modification,transcriptional regulation to protein transla tion.The study on lncRNA has made great progress in the studies of genomic imprinting,cancer diseases and neurodegenerative disorders,while the research relevant to autoimmune diseases has just staaed recently,However,many lncRNAs have been identified to involve in immune cells proliferation,differentiation and maturation,acting as the key regulators in immune homeostasis and autoimmune diseases.This review is focused on the advances of lncRNA in immune cells and autoimmune diseases.
