Effects of immunoglobulin treatment in infantile pneumonia and therapeutic impact on blood immunoglobulin levels
10.3969/j.issn.1000-484X.2017.06.022
- VernacularTitle:免疫球蛋白佐治婴幼儿肺炎的效果及对患儿免疫功能水平的影响
- Author:
Yumei REN
;
Xiaobing LI
;
Jianghong HOU
;
Shan ZHU
;
Haijun SHAN
- Keywords:
Immunoglobulin;
Severe pneumonia;
Immune function
- From:
Chinese Journal of Immunology
2017;33(6):914-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical effect of intravenous immunoglobulin combined with conventional therapy in the treatment of severe pneumonia in infants and children.Methods:Selected the January 2015 to April 2016 in our hospital for treatment of 88 cases of children with severe pneumonia were retrospectively analyzed,which 47 cases by routine treatment plus intravenous immunoglobulin protein (treatment group),41 cases of children only take routine therapy (control group),with a course of 2 weeks.Results:The symptoms of fever,dyspnea,cough,wheezing,pulmonary rales were improved faster in the treatment group than the control group (P＜0.05);after 2 weeks of treatment,IgG levels were significantly higher in the treatment group than the control group(P＜0.05);after 2 weeks of treatment,the serum IL-6 and TNF-α levels were significantly lower in the treatment group than the control group(P＜ 0.05);after 1 week of treatment,57.45％ of patients was cured in the treatment groups while only 34.15％ patients in the control group (P＜0.05).Conclusion:Intravenous immunoglobulin combined with conventional therapy in the treatment of infants with severe pneumonia can significantly improve the theraputic effect and enhance blood immunoglobulin levels.
