Updated insights into the pathogenesis of sepsis
10.16571/j.cnki.1008-8199.2017.07.002
- VernacularTitle:脓毒症发病机制最新认识
- Author:
Yongming YAO
;
Yanmin ZHANG
- Keywords:
Sepsis;
Inflammatory response;
Immune dysfunction;
Abnormal blood coagulation
- From:
Journal of Medical Postgraduates
2017;30(7):678-683
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis and septic shock are common critical diseases in the ICU, which have a high mortality and seriously affect the patients'' quality of life.The pathogenesis of sepsis is very complicated and involves the changes in the functions of multiple systems and organs.Recently, the investigation into the potential mechanisms underlying the development of sepsis is becoming a hotspot all over the world.The author presents an overview on the advances in the studies of the pathogenesis of sepsis, relating to the imbalance of inflammatory response, immune dysfunction, abnormal blood coagulation, nerve-endocrine-immunity network, mitochondrial function damage, endoplasmic reticulum stress, autophagy, and genetic polymorphism, in order to provide some theoretical evidence for the prevention and treatment of sepsis in clinical practice.
