The research progress for the role of reactive oxygen species in the occurrence of noise-induced hearing loss

VernacularTitle:活性氧在噪声性听力损伤发生中的作用研究进展
Author: Lingyuan TANG
Keywords: Reactive oxygen speices; Noise-induced hearing loss; Noise exposure
From: Journal of Medical Postgraduates 2017;30(7):770-774
CountryChina
Language:Chinese
Abstract: Noise-induced hearing loss (NIHL) is defined by a strong noise exposure led up the hair cells to damage which caused sensorineural hearing loss.The occurrence of NIHL is mainly related to oxidative damage, such as reactive oxygen species.Oxidative damage is mainly related to the ROS produced by noise exposure which can cause cochlear ischemia, hypoxia, and mitochondrial damage, resulting in hair cell death, further led to hearing loss.Prevention or treatment measures of NIHL is to reduce the formation of ROS and the removal of ROS.Antioxidants have been used in clinical treatment.This article reviews the effects of reactive oxygen species in NIHL to further explore the pathogenesis and prevention or treatment measures of NIHL.