Low-frequency fluctuation amplitude analysis of resting-state fMRI for functional brain response differences between acupuncture and moxibustion at Zusanli (ST 36) in patient with functional dyspepsia
10.1007/s11726-017-1006-y
- VernacularTitle:静息态fMRI低频振幅评价针刺与艾灸功能性消化不良患者足三里脑功能响应差异
- Author:
Mailan LIU
;
Can LIU
;
Jing WU
;
Bo LI
;
Zhigen ZHOU
;
Peishan DAI
;
Jie YU
;
Xiaorong CHANG
;
Chouping HAN
- Keywords:
Acupuncture Therapy;
Moxibustion Therapy;
Moxa Stick Moxibustion;
Point;
Zusanli (ST 36);
Research on Acupoints;
Dyspepsia;
Magnetic Resonance Imaging
- From:
Journal of Acupuncture and Tuina Science
2017;15(4):230-236
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare and analyze functional brain response characteristics by applying acupuncture or moxibustion to Zusanli (ST 36) in patients with functional dyspepsia (FD) and investigate the differences of central action mechanism resulting from acupuncture or moxibustion. Methods: A total of eligible 24 FD cases were divided into two blood-oxygen-level dependent (BOLD) sequences for functional magnetic resonance imaging (fMRI) scan. The amplitude of low frequency fluctuation (ALFF) analyses were conducted on the data of location phase, structure phase, resting state before acupuncture/moxibustion, working state during acupuncture/moxibustion and resting state after acupuncture/moxibustion using Data Processing Assistant for Resting-State fMRI (DPARSF) software. Results: Acupuncture and moxibustion produced significant differences in functional brain response. The working state during acupuncture/moxibustion mainly decreased ALFF values in the right supramarginal gyrus, right superior parietal lobule, right frontal gyrus, upper right occipital lobe, right precuneus and right cingulate gyrus. At the same time, it increased ALFF values in the left cerebellum, right caudate nucleus, right cerebellum and left inferior gyrus. The differences during the resting state after acupuncture/moxibustion were significantly smaller than the working state in intensity and size. It mainly resulted in decrease in ALFF values in the right postcentral gyrus and right supramarginal gyrus and increase in ALFF values in the left precuneus, orbital part of inferior frontal gyrus and right cerebellar peduncles. Conclusion: Needling and moxibustion at Zusanli (ST 36) can produce significant differences in immediate functional brain response.
